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S-腺苷甲硫氨酸（SAM-e，SAMe，SAM，AdoMet，ademetionine）由GL Cantoni于1952年在意大利發現。它是由三磷酸腺苷（ATP）和甲硫氨酸經甲硫氨酸腺苷轉移酶制成的。S-腺苷甲硫氨酸是大多數生物體中的關鍵代謝物。它通過脫羧作用發揮重要的轉甲基、轉硫和氨丙基化功能。
由于 SAM 是一種本質上不穩定的分子，其 258-260 nm 的最大光密度不是顯著的吸收，因此測定其在各種生物體液和組織中的濃度一直是一項具有挑戰性的任務。一種不需要昂貴儀器（LC、MS 和組合）的簡單、方便的方法顯然是確定 SAM 的生物濃度以及監測其在體液、組織和細胞器中的變化和代謝路徑的理想選擇。
據稱 SAM-e 有助于以下疾病：抑郁癥、帕金森病、骨關節炎癥狀、肝病、肝內膽汁淤積癥（尤其是妊娠期）、纖維肌痛、艾滋病相關的脊髓病（與艾滋病相關的脊柱和神經疾病）。也有有限的研究參考了 SAMe 在以下情況中的作用：注意力缺陷多動障礙 (ADHD)、經前期綜合征 (PMS)、經前期煩躁癥 (PMDD)、慢性疲勞綜合征 (CFS)、心臟病、智力缺陷表現、多發性硬化、癡呆、阿爾茨海默病、肌腱炎、滑囊炎、脊髓損傷、癲癇發作、偏頭痛、慢性腰痛、鉛中毒和衰老。
如今，當 SAM 每天用作營養補充劑時，了解其影響和后果也是至關重要的。它已被廣泛用作非處方藥，以緩解抑郁癥、骨關節炎等系統。
Arthus Biosystems 很高興提供一系列研究試劑和試劑盒，以幫助開展與蛋氨酸循環相關的科學研究，蛋氨酸循環是所有生物體進化過程中保守的關鍵生化途徑。我們的 SAM 和 SAH 單克隆抗體具有非常高的滴度和親和力，讓您只需一瓶即可完成大部分研究。迄今為止，我們的抗 SAM 和 SAH 抗體均具有*佳靈敏度。我們還提供經過驗證的 SAM 和 SAH 偶聯物以及生物s等示蹤分子，以幫助您研究生物分子-生物分子的相互作用并開發進一步的檢測方法。
上海起發arthusbio2022年產品目錄
| Catalog No. | Name | Description | Packaging |
|---|---|---|---|
| Immunoassay Kits and Strips | |||
| IK00201 | SAM ELISA | S-adenosylmethionine ELISA kit | 96 tests |
| IK00201s | SAM ELISA s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples | 96 tests |
| IK00202 | SAM ELISA 2 | S-adenosylmethionine ELISA kit, broad range | 96 tests |
| IK00202s | SAM ELISA 2s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 96 tests |
| IK00203 | SAM ELISA 3 | S-adenosylmethionine ELISA kit, broad range | 48 tests |
| IK00203s | SAM ELISA 3s | S-adenosylmethionine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 48 tests |
| IK00204 | SAM ELISA 4 | S-adenosylmethionine ELISA kit for cell culture supernatant or other samples | 96 tests |
| IK00301 | SAH ELISA | S-adenosylhomocysteine ELISA kit | 96 tests |
| IK00301s | SAH ELISA s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples | 96 tests |
| IK00302 | SAH ELISA 2 | S-adenosylhomocysteine ELISA kit, broad range | 96 tests |
| IK00302s | SAH ELISA 2s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 96 tests |
| IK00303 | SAH ELISA 3 | S-adenosylhomocysteine ELISA kit, broad range | 48 tests |
| IK00303s | SAH ELISA 3s | S-adenosylhomocysteine ELISA kit for plasma, serum, or tissue/cell homogenate samples, broad range | 48 tests |
| IK00304 | SAH ELISA 4 | S-adenosylhomocysteine ELISA kit for cell culture supernatant or other samples | 96 tests |
| IK00401 | MAT Activity Assay | Methionine Adenosyltransferase (MAT) activity assay kit | 96 tests |
| IK00403 | MAT Activity Assay 3 | Methionine Adenosyltransferase (MAT) activity assay kit | 48 tests |
| Antibodies and Conjugates | |||
| MA00201-50 | Mouse anti-SAM 1b | Mouse monoclonal antibody to S- denosylmethionine Clone 118-6 | 100µg |
| MA00201-100 | Mouse anti-SAM 1a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 118-6 | 50µg |
| MA00202-50 | Mouse anti-SAM 2a | Mouse monoclonal antibody to S- denosylmethionine Clone 84-3 | 50µg |
| MA00202-100 | Mouse anti-SAM 2b | Mouse monoclonal antibody to S-Adenosylmethionine Clone 84-3 | 100µg |
| MA00203-50 | Mouse anti-SAM 3a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 118-18 | 50µg |
| MA00204-50 | Mouse anti-SAM 4a | Mouse monoclonal antibody to S-Adenosylmethionine Clone 84-19 | 50µg |
| PA00201-50 | Rabbit anti-SAM a | Rabbit polyclonal antibody to S-Adenosylmethionine | 50µg |
| PA00201-100 | Rabbit anti-SAM b | Rabbit polyclonal antibody to S-Adenosylmethionine | 100µg |
| MA00301-50 | Mouse anti-SAH 1a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-1 | 50µg |
| MA00302-50 | Mouse anti-SAH 2a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-10 | 50µg |
| MA00303-50 | Mouse anti-SAH 3a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-3 | 50µg |
| MA00304-50 | Mouse anti-SAH 4a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 301-16 | 50µg |
| MA00305-50 | Mouse anti-SAH 5a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-1 | 50µg |
| MA00306-50 | Mouse anti-SAH 6a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 844-2 | 50µg |
| MA00307-50 | Mouse anti-SAH 7a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 839-6 | 50µg |
| MA00308-50 | Mouse anti-SAH 8a | Mouse monoclonal antibody to S-Adenosylhomocysteine Clone 839-12 | 50µg |
| MAF00201-25 | AF6-anti-SAM 1a | Alexa Fluor® 647 (AF6) conjugated anti-SAM monoclonal antibody Clone 118-6 | 25µg |
| MAF00201-50 | AF6-anti-SAM 1b | Alexa Fluor® 647 (AF6) conjugated anti-SAM monoclonal antibody Clone 118-6 | 50µg |
| MAF00202-50 | AF6-anti-SAM 2a | Phycoerythrin (PE) conjugated anti-SAM monoclonal antibody Clone 84-3 | 50µg |
| MAF00301-25 | AF488-anti-SAH 1a | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 301-3 | 25µg |
| MAF00301-50 | AF488-anti-SAH 1b | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 301-3 | 50µg |
| MAF00302-50 | AF488-anti-SAH 2a | Alexa Fluor® 488 (AF488) conjugated anti-SAH monoclonal antibody Clone 839-6 | 50µg |
| MAH00201-50 | HRP-anti-SAM 1a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 118-6 | 50µl |
| MAH00202-50 | HRP-anti-SAM 2a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 84-3 | 50µl |
| MAH00203-50 | HRP-anti-SAM 3a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 118-18 | 50µl |
| MAH00204-50 | HRP-anti-SAM 4a | Horseradish peroxidase (HRP) conjugated anti-SAM monoclonal antibody Clone 84-19 | 50µl |
| MAH00301-50 | HRP-anti-SAH 1a | Horseradish peroxidase (HRP) conjugated anti-SAH monoclonal antibody Clone 301-3 | 50µl |
| MAH00302-50 | HRP-anti-SAH 2a | Horseradish peroxidase (HRP) conjugated anti-SAH monoclonal antibody Clone 301-16 | 50µl |
| MAH00701-50 | HRP-anti-DIG | Peroxidase-conjugated IgG Fraction Monoclonal Mouse Anti-Digoxigenin | 50µl |
| PA00401-50 | Rabbit anti-MAT s | Rabbit polyclonal antiserum against methionine adenosyltransferase | 50µl |
| PA00401-50 | Rabbit anti-MAT g | Rabbit polyclonal antiserum against methionine adenosyltransferase (with glycerol) | 50µl |
| Compounds and Conjugates | |||
| AST00201 | Aza-SAM | A series of S-adenosylmethionine analog Aza-SAM standards: 500nM, 250nM, 125nM, 62.5nM, 31.25nM, 15.625nM, 7.8125nM, 0nM | 1ml |
| AST00201-1 | Aza-SAM a | S-adenosylmethionine analog Aza-SAM standard. Buffer (4 ml) for serial dilution may be supplied (additional $15 each). | 1ml (500nM) |
| AST00201-200 | Aza-SAM b | S-adenosylmethionine analog Aza-SAM standard. Buffer (10 ml) for serial dilution may be supplied (additional $15 each). | 200ul (5µM) |
| AST00201-1s | Aza-SAM as | S-adenosylmethionine analog Aza-SAM standard for serum/plasma. Buffer (3.2 ml) for serial dilution may be supplied. | 1ml (1µM) |
| ACT00201-5 | PLL-aza-SAM a | Poly-lysine was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 10-20 96-well micro-titer plates. | 5µg |
| ACT00201-10 | PLL-aza-SAM b | Poly-lysine was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 20-40 96-well micro-titer plates. | 10µg |
| ACT00202-50 | Bio-SAM a | Biotin is conjugated to NH2 group of S-adenosylmethionine. | 50µg |
| ACT00202-100 | Bio-SAM b | Biotin is conjugated to NH2 group of S-adenosylmethionine. | 100µg |
| ACT00203-50 | Bio-6C-SAM 1a | Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. | 50µg |
| ACT00203-100 | Bio-6C-SAM 1b | Biotin is conjugated to NH2 of SAM through 6-aminohexanoic acid. | 100µg |
| ACT00204-5 | BSA-aza-SAM a | Bovine serum Albumin was conjugated to S-adenosylmethionine analog Aza-SAM (AST00201). Coating for 10-20 96-well micro-titer plates. | 5µg |
| ACT00205-10 | Bio-6C-aza-SAM 1a | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 10µg |
| ACT00205-50 | Bio-6C-aza-SAM 1b | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 50µg |
| ACT00205-100 | Bio-6C-aza-SAM 1c | Biotin is conjugated to the NH2 of aza-SAM through 6-aminohexanoic acid. | 100µg |
| ACT00206-10 | Bio-12CN-aza-SAM 1a | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 10µg |
| ACT00206-50 | Bio-12CN-aza-SAM 1b | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 50µg |
| ACT00206-100 | Bio-12CN-aza-SAM 1c | Biotin is conjugated to the NH2 of aza-SAM through a 10-carbon and 2-nitrogen linker. | 100µg |
| AST00301-1 | SAH-Na | S-Adenosylhomocysteine standard ( SAH Sodium). Buffer (18 ml) for serial dilution may be supplied (additional $15 each). | 1ml (4µM) |
| AST00301-1s | SAH-Na s | S-Adenosylhomocysteine standard ( SAH Sodium) for serum/plasma. Buffer (8ml) for serial dilution may be supplied (additional $60 each). | 0.5ml (4µM) |
| ACT00301-50 | BSA-SAH | BSA was conjugated to S-Adenosylhomocysteine. Coating for 10 96-well micro-titer plates. | 50µg (20µg) |
| ACT00302-50 | Bio-SAH a | Biotin is conjugated to NH2 group of S-adenosylhomocysteine. | 50µg |
| ACT00302-100 | Bio-SAH b | Biotin is conjugated to NH2 group of S-adenosylhomocysteine. | 100µg |
| ACT00303-50 | Bio-6C-SAH 1a | Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. | 50µg |
| ACT00303-100 | Bio-6C-SAH 1b | Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid. | 100µg |
| ACT00304-25 | Dig-6C-SAH 1a | Digoxin is conjugated to NH2- of SAH through 6-bromocaproic acid | 25µg |
| ACT00304-50 | Dig-6C-SAH 1b | Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid. | 50µg |
| ACT00304-100 | Dig-6C-SAH 1c | Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid. | 100µg |
| ACT00305-10 | Bio-12CN-SAH 1a | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 10µg |
| ACT00305-50 | Bio-12CN-SAH 1b | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 50µg |
| ACT00305-100 | Bio-12CN-SAH 1c | Biotin is conjugated to NH2 of SAH through a 10-carbon and 2-nitrogen linker. | 100µg |
| AST00401-50 | MAT a | Recombinant methionine adenosyltransferase (E.C. 2.5.1.6), E. Coli expression | 50µg |
| AST00401-500 | MAT b | Recombinant methionine adenosyltransferase (E.C. 2.5.1.6), E. Coli expression | 500µg |
| ACT00501-100 | BSA-HCY | Bovine serum albumin (BSA) was conjugated to homocysteine (HCY). | 100µg |
| AST00601-50 | HMT a | Recombinant Homocysteine S-methyltransferase (E.C. 2.1.1.10), E. Coli expression | 50µg |
| AST00601-500 | HMT b | Recombinant Homocysteine S-methyltransferase (E.C. 2.1.1.10), E. Coli expression | 500µg |
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